Article
Ribosomal s6 kinase cooperates with casein kinase 2 to modulate the Drosophila circadian molecular oscillator.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2009
Akten Bikem, Tangredi Michelle M, Jauch Eike, Roberts Mary A, Ng Fanny, Raabe Thomas, Jackson F Rob
Abstract excerpt
There is a universal requirement for post-translational regulatory mechanisms in circadian clock systems. Previous work in Drosophila has identified several kinases, phosphatases, and an E3 ligase that are critical for determining the nuclear translocation and/or stability of clock proteins. The present study evaluated the function of p90 ribosomal S6 kinase (RSK) in the Drosophila circadian system. In mammals,...
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