Article
Ribosomal s6 kinase cooperates with casein kinase 2 to modulate the Drosophila circadian molecular oscillator.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2009
Akten Bikem, Tangredi Michelle M, Jauch Eike, Roberts Mary A, Ng Fanny, Raabe Thomas, Jackson F Rob
Abstract excerpt
There is a universal requirement for post-translational regulatory mechanisms in circadian clock systems. Previous work in Drosophila has identified several kinases, phosphatases, and an E3 ligase that are critical for determining the nuclear translocation and/or stability of clock proteins. The...
Topics
- Animals
- Animals, Genetically Modified
- Casein Kinase II
- Cell Line, Transformed
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Humans
- Motor Activity
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Periodicity