Article
An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.
G3 (Bethesda, Md.) - 7 Dec 2016
Agrawal Parul, Hardin Paul E
Abstract excerpt
Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period (per) and timeless (tim) genes, rising levels of PER-TIM complexes feed-back to repress CLK-CYC activity, and degradation of PER and TIM permits the next cycle of...
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