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Article

An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.

G3 (Bethesda, Md.) - 7 Dec 2016

Agrawal Parul, Hardin Paul E

Abstract excerpt

Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period (per) and timeless (tim) genes, rising levels of PER-TIM complexes feed-back to repress CLK-CYC activity, and degradation of PER and TIM permits the next cycle of...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Circadian Clocks
Circadian Rhythm
Drosophila
Drosophila Proteins
Gene Expression Regulation
Gene Knockdown Techniques
Genetic Testing
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphoprotein Phosphatases

RNA Interference

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27784754
DOI: 10.1534/g3.116.035345
PMCID: PMC5144990

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27784754-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.PMID 27784754Read ↗

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CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

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