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Article

A circadian sleep disorder reveals a complex clock.

Cell - 12 Jan 2007

Mignot Emmanuel, Takahashi Joseph S

Abstract excerpt

Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and...

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Source

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Identifiers

PMID: 17218251
DOI: 10.1016/j.cell.2006.12.024
PMCID: PMC3758472

Genes

PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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A circadian sleep disorder reveals a complex clock.PMID 17218251Read ↗

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Endogenous circadian reporter cell lines as an efficient platform for studying circadian mechanismsSemantic proximity Read ↗

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.Semantic proximity Read ↗

Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.Semantic proximity Read ↗

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