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Article

Positive epistasis drives the acquisition of multidrug resistance.

PLoS genetics - 1 Jul 2009

Trindade Sandra, Sousa Ana, Xavier Karina Bivar, Dionisio Francisco, Ferreira Miguel Godinho, Gordo Isabel

Abstract excerpt

The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact--epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a...

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Identifiers

PMID: 19629166
DOI: 10.1371/journal.pgen.1000578
PMCID: PMC2706973

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Source receipt: pubmed, retrieved 7 Sept 2026.

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