Article
Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.
Genome biology - 18 Jul 2018
Yokoyama Maho, Stevens Emily, Laabei Maisem, Bacon Leann, Heesom Kate, Bayliss Sion, Ooi Nicola, O'Neill Alex J, Murray Ewan, Williams Paul, Lubben Anneke, Reeksting Shaun, Meric Guillaume, Pascoe Ben, Sheppard Samuel K, Recker Mario, Hurst Laurence D, Massey Ruth C
Abstract excerpt
BACKGROUND: Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported as being cost-free, which suggests that there are few barriers preventing their global spread. However, this is not...
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