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Article

Source–sink dynamics shape the evolution of antibiotic resistance and its pleiotropic fitness cost

24 Jul 2007

Abstract excerpt

Understanding the conditions that favour the evolution and maintenance of antibiotic resistance is the central goal of epidemiology. A crucial feature explaining the adaptation to harsh, or 'sink', environments is the supply of beneficial mutations via migration from a 'source' population. Given that antibiotic resistance is frequently associated with antagonistic pleiotropic fitness costs, increased migration...

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PMID: 17650474
DOI: 10.1098/rspb.2007.0640

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