Article
The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.
Molecular biology of the cell - 1 May 2009
Zuo Xiaofeng, Guo Wei, Lipschutz Joshua H
Abstract excerpt
Primary cilia are found on many epithelial cell types, including renal tubular epithelial cells, in which they are felt to participate in flow sensing and have been linked to the pathogenesis of cystic renal disorders such as autosomal dominant polycystic kidney disease. We previously localized the exocyst, an eight-protein complex involved in membrane trafficking, to the primary cilium of Madin-Darby canine...
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