Article
The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.
PLoS genetics - 1 Apr 2011
Fogelgren Ben, Lin Shin-Yi, Zuo Xiaofeng, Jaffe Kimberly M, Park Kwon Moo, Reichert Ryan J, Bell P Darwin, Burdine Rebecca D, Lipschutz Joshua H
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and other proteins are targeted to cilia. Here, we provide the first genetic and biochemical link between polycystins and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.