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Article

The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.

PLoS genetics - 1 Apr 2011

Fogelgren Ben, Lin Shin-Yi, Zuo Xiaofeng, Jaffe Kimberly M, Park Kwon Moo, Reichert Ryan J, Bell P Darwin, Burdine Rebecca D, Lipschutz Joshua H

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and othe...

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Share to Cilia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21490950
DOI: 10.1371/journal.pgen.1001361
PMCID: PMC3072367

Genes

IFT20
IFT88
PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21490950-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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