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Exocyst Requirement for Endocytic Traffic Directed Toward the Apical and Basolateral Poles of Polarized MDCK Cells

9 Aug 2007

Abstract excerpt

The octameric exocyst complex is associated with the junctional complex and recycling endosomes and is proposed to selectively tether cargo vesicles directed toward the basolateral surface of polarized Madin-Darby canine kidney (MDCK) cells. We observed that the exocyst subunits Sec6, Sec8, and Exo70 were localized to early endosomes, transferrin-positive common recycling endosomes, and Rab11a-positive apical...

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PMID: 17686995
DOI: 10.1091/mbc.e07-02-0097

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Exocyst Requirement for Endocytic Traffic Directed Toward the Apical and Basolateral Poles of Polarized MDCK CellsPMID 17686995Read ↗

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The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.Semantic proximity Read ↗

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Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.Semantic proximity Read ↗

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent mannerSemantic proximity Read ↗

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Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth.Semantic proximity Read ↗

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An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

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