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Article

Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.

Journal of the American Society of Nephrology : JASN - 1 Sept 2013

Choi Soo Young, Chacon-Heszele Maria F, Huang Liwei, McKenna Sarah, Wilson F Perry, Zuo Xiaofeng, Lipschutz Joshua H

Abstract excerpt

Ciliogenesis and cystogenesis require the exocyst, a conserved eight-protein trafficking complex that traffics ciliary proteins. In culture, the small GTPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst component Sec10. The role of Cdc42 in vivo, however, is not well understood. Here, knockdown of cdc42 in zebrafish produced a phenotype similar to sec10 knockdown, including...

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Identifiers

PMID: 23766535
DOI: 10.1681/ASN.2012121236
PMCID: PMC3752951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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