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Article

Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.

Journal of the American Society of Nephrology : JASN - 1 Sept 2013

Choi Soo Young, Chacon-Heszele Maria F, Huang Liwei, McKenna Sarah, Wilson F Perry, Zuo Xiaofeng, Lipschutz Joshua H

Abstract excerpt

Ciliogenesis and cystogenesis require the exocyst, a conserved eight-protein trafficking complex that traffics ciliary proteins. In culture, the small GTPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst component Sec10. The role of Cdc42 in vivo, however, is...

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Source

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Identifiers

PMID: 23766535
DOI: 10.1681/ASN.2012121236
PMCID: PMC3752951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23766535-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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