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Article

A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.

The Journal of biological chemistry - 4 May 2012

Feng Shanshan, Knödler Andreas, Ren Jinqi, Zhang Jian, Zhang Xiaoyu, Hong Yujuan, Huang Shaohui, Peränen Johan, Guo Wei

Abstract excerpt

Primary cilia are microtubule-based solitary membrane projections on the cell surface that play important roles in signaling and development. Recent studies have demonstrated that polarized vesicular trafficking involving the small GTPase Rab8 and its guanine nucleotide exchange factor Rabin8 is essential for primary ciliogenesis. In this study, we show that a highly conserved region of Rabin8 is pivotal for its...

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Identifiers

PMID: 22433857
DOI: 10.1074/jbc.M111.333245
PMCID: PMC3346093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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