Article
Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development.
Kidney international - 1 Dec 2025
Okushima Hiroki, Inoue Kazunori, Imai Atsuhiro, Matsumoto Ayumi, Tamai Natsune, Kunii Masataka, Iriuchijima Nobuhisa, Adam Rüdiger, Al Rawahi Yusriya, Al Sinani Siham, Yamamoto Takeshi, Mizui Masayuki, Harada Akihiro, Yanagita Motoko, Isaka Yoshitaka, Matsui Isao
Abstract excerpt
INTRODUCTION: Epithelial cell polarity is crucial for the proper functioning of various organs, including the kidneys. Syntaxin 3, a key molecule in membrane-vesicle fusion, is localized in the apical membrane of proximal tubule epithelial cells (PTECs). Although in vitro studies using the other type of epithelial cells besides PTECs have shown the role of syntaxin 3 in regulating apical membrane integrity, its...
Read the complete abstract on PubMedTopics
- Animals
- Kidney Tubules, Proximal
- Fanconi Syndrome
- Mice, Knockout
- Epithelial Cells