Article

Conditional Loss of the Exocyst Component exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photo-Receptor Cell Degeneration, and Decreased Visual Function.

2021-04-07

Abstract excerpt

To characterize the mechanisms by which the highly-conserved exocyst trafficking complex regulates eye physiology in zebrafish and mice, we focused on exoc5 (aka sec10), a central exocyst component. We analyzed both exoc5 zebrafish mutants and retinal pigmented epithelium (RPE)-specific Exoc5 knockout mice. Exoc5 is present in both the non-pigmented epithelium of the ciliary body and in the RPE. In this study we s...

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Literature Corpus work: 0e2d0b42-6801-5d24-bf3a-cb4e39639205
DOI: 10.20944/preprints202104.0191.v1

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