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Article

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.

The EMBO journal - 15 Feb 1999

Guo W, Roth D, Walch-Solimena C, Novick P

Abstract excerpt

Polarized secretion requires proper targeting of secretory vesicles to specific sites on the plasma membrane. Here we report that the exocyst complex plays a key role in vesicle targeting. Sec15p, an exocyst component, can associate with secretory vesicles and interact specifically with the rab G...

Topics

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Centrifugation, Density Gradient
Cytoplasmic Granules
Exocytosis
GTP-Binding Proteins
Microscopy, Immunoelectron
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rab GTP-Binding Proteins

Vesicular Transport Proteins

Source

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Identifiers

PMID: 10022848
DOI: 10.1093/emboj/18.4.1071
PMCID: PMC1171198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10022848-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.PMID 10022848Read ↗

The rab exchange factor Sec2p reversibly associates with the exocyst.Semantic proximity Read ↗

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.Semantic proximity Read ↗

A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.Semantic proximity Read ↗

Exocyst Requirement for Endocytic Traffic Directed Toward the Apical and Basolateral Poles of Polarized MDCK CellsSemantic proximity Read ↗

Cyclical regulation of the exocyst and cell polarity determinants for polarized cell growth.Semantic proximity Read ↗

The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6pSemantic proximity Read ↗

Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p.Semantic proximity Read ↗

Membrane targeting of the yeast exocyst complex.Semantic proximity Read ↗

The beta subunit of the Sec61p endoplasmic reticulum translocon interacts with the exocyst complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosisSemantic proximity Read ↗

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent mannerSemantic proximity Read ↗

Cdc42 interacts with the exocyst and regulates polarized secretion.Semantic proximity Read ↗

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