Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.

Oxidative medicine and cellular longevity - 1 Jan 2015

Porcellotti Sara, Fanelli Francesca, Fracassi Anna, Sepe Sara, Cecconi Francesco, Bernardi Cinzia, Cimini AnnaMaria, Cerù Maria Paola, Moreno Sandra

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration. Pathogenetic mechanisms, triggered by β-amyloid (Aβ) accumulation, include oxidative stress, derived from energy homeostasis deregulation and involving mitochondria and peroxisomes. We he...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glial Fibrillary Acidic Protein
Share to Glutathione Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Peroxidase GPX1

Share to Neocortex

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Peroxisomes

Share to PPAR alpha

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 25973140
DOI: 10.1155/2015/967203
PMCID: PMC4418010

Genes

GFAP
GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25973140-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.PMID 25973140Read ↗

Aging and Neurodegeneration: A Tangle of Models and MechanismsSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and TreatmentSemantic proximity Read ↗

Disentangling Mitochondria in Alzheimer’s DiseaseSemantic proximity Read ↗

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studiesSemantic proximity Read ↗

The role of mitochondrial defects and oxidative stress in Alzheimer’s diseaseSemantic proximity Read ↗

Is oxidative damage central to the pathogenesis of Alzheimer disease?Semantic proximity Read ↗

The Role of PGC1α in Alzheimer’s Disease and Therapeutic InterventionsSemantic proximity Read ↗

Early mitochondrial dysfunction proceeds neuroinflammation, synaptic alteration, and autophagy impairment in hippocampus of <i>App</i> knock-in Alzheimer mouse modelsSemantic proximity Read ↗

Involvement of oxidative stress in Alzheimer disease.Semantic proximity Read ↗

Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s diseaseSemantic proximity Read ↗

Oxidative stress in neurodegeneration: cause or consequence?Semantic proximity Read ↗

Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.