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Intracellular A? and its Pathological Role in Alzheimer's Disease: Lessons from Cellular to Animal Models

25 Mar 2016

Abstract excerpt

Accumulation of intraneuronal amyloid-β peptide (Aβ) appears to be an early event in Alzheimer's disease (AD), suggesting its important role in the neurodegenerative process of AD. It is indicated that intracellular Aβ originates from a portion of Aβ, which is not secreted and consequently remains intracellular, or alternatively from the secreted Aβ, which is internalized into intracellular Aβ pool. A number of...

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PMID: 27001677
DOI: 10.2174/1567205013666160322142226

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