Article
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia.
Scientific reports - 24 Oct 2017
Urbaneja María A, Skjærven Lars, Aubi Oscar, Underhaug Jarl, López David J, Arregi Igor, Alonso-Mariño Marián, Cuevas Andoni, Rodríguez José A, Martinez Aurora, Bañuelos Sonia
Abstract excerpt
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia (AML). We have performed a high-throughput screening searching for compounds that stabilize the C-terminal domain. We identified three hit compounds which show the ability to increase the...
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