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Article

Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.

PLoS genetics - 1 Mar 2009

Liu Yao-Zhong, Guo Yan-Fang, Wang Liang, Tan Li-Jun, Liu Xiao-Gang, Pei Yu-Fang, Yan Han, Xiong Dong-Hai, Deng Fei-Yan, Yu Na, Zhang Yin-Ping, Zhang Lei, Lei Shu-Feng, Chen Xiang-Ding, Liu Hong-Bin, Zhu Xue-Zhen, Levy Shawn, Papasian Christopher J, Drees Betty M, Hamilton James J, Recker Robert R, Deng Hong-Wen

Abstract excerpt

For females, menarche is a most significant physiological event. Age at menarche (AAM) is a trait with high genetic determination and is associated with major complex diseases in women. However, specific genes for AAM variation are largely unknown. To identify genetic factors underlying AAM varia...

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Identifiers

PMID: 19282985
DOI: 10.1371/journal.pgen.1000420
PMCID: PMC2652107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19282985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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