Article
Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.
PLoS genetics - 1 Mar 2009
Liu Yao-Zhong, Guo Yan-Fang, Wang Liang, Tan Li-Jun, Liu Xiao-Gang, Pei Yu-Fang, Yan Han, Xiong Dong-Hai, Deng Fei-Yan, Yu Na, Zhang Yin-Ping, Zhang Lei, Lei Shu-Feng, Chen Xiang-Ding, Liu Hong-Bin, Zhu Xue-Zhen, Levy Shawn, Papasian Christopher J, Drees Betty M, Hamilton James J, Recker Robert R, Deng Hong-Wen
Abstract excerpt
For females, menarche is a most significant physiological event. Age at menarche (AAM) is a trait with high genetic determination and is associated with major complex diseases in women. However, specific genes for AAM variation are largely unknown. To identify genetic factors underlying AAM variation, a genome-wide association study (GWAS) examining about 380,000 SNPs was conducted in 477 Caucasian women. A...
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