Article
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
American journal of human genetics - 5 May 2016
Mbarek Hamdi, Steinberg Stacy, Nyholt Dale R, Gordon Scott D, Miller Michael B, McRae Allan F, Hottenga Jouke Jan, Day Felix R, Willemsen Gonneke, de Geus Eco J, Davies Gareth E, Martin Hilary C, Penninx Brenda W, Jansen Rick, McAloney Kerrie, Vink Jacqueline M, Kaprio Jaakko, Plomin Robert, Spector Tim D, Magnusson Patrik K, Reversade Bruno, Harris R Alan, Aagaard Kjersti, Kristjansson Ragnar P, Olafsson Isleifur, Eyjolfsson Gudmundur Ingi, Sigurdardottir Olof, Iacono William G, Lambalk Cornelis B, Montgomery Grant W, McGue Matt, Ong Ken K, Perry John R B, Martin Nicholas G, Stefánsson Hreinn, Stefánsson Kari, Boomsma Dorret I
Abstract excerpt
Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.