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Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.

Journal of human genetics - 1 May 2023

Tsai Meng-Che, Hsu Chih-Hui, Chu Shih-Kai, Roy-Gagnon Marie-Hélène, Lin Sheng-Hsiang

Abstract excerpt

Sexual maturation is a complex physiological process that involves multiple variables, such as genetic and environmental factors. Among females, age at menarche (AM) is a critical milestone for sexual maturation. This study aimed to identify genetic markers of AM using nationwide population cohort data in Taiwan. Females with self-reported AM between 10 and 16 years (N = 39,827) were eligible for the final...

Topics

Humans
Female
Genome-Wide Association Study
Menarche
Genetic Markers
Biological Specimen Banks
Taiwan
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ubiquitin-Protein Ligases

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PMID: 36710296
DOI: 10.1038/s10038-023-01124-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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