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Article

Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background.

Neurobiology of aging - 1 Feb 2011

Katzav Aviva, Faust-Socher Achinoam, Kvapil Filip, Michaelson Daniel M, Blank Miri, Pick Chaim G, Shoenfeld Yehuda, Korczyn Amos D, Chapman Joab

Abstract excerpt

The antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) and vascular brain disease which is often associated with dementia. We examined the neurodegenerative pathological processes underlying APS by inducing APS in a transgenic animal model of Alzheimer's disease. Female C57B6/SJL mice carrying the APP(695)SWE mutation (Tg2576) and wild-type (wt) controls were immunized with...

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Source

Identifiers

PMID: 19282067
DOI: 10.1016/j.neurobiolaging.2009.02.007

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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