Article
Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice.
Neurobiology of disease - 1 Dec 2003
Wang Jun, Tanila Heikki, Puoliväli Jukka, Kadish Inga, van Groen Thomas
Abstract excerpt
Transgenic mice carrying both the human amyloid precursor protein (APP) with the Swedish mutation and the presenilin-1 A246E mutation (APP/PS1 mice) develop Alzheimer's disease-like amyloidbeta protein (Abeta) deposits around 9 months of age. These mice show an age-dependent increase in the level of Abeta40 and Abeta42 and in the number of amyloid plaques in the brain. Abeta40 and Abeta42 levels were measured,...
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