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Article

Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's disease model.

Behavioural brain research - 1 Apr 2013

Ferguson Sherry A, Sarkar Sumit, Schmued Larry C

Abstract excerpt

The APP/PS1 double transgenic mouse is an Alzheimer's Disease-like model. However, cognitive deficits measured at one age do not necessarily indicate age-related progressions. Further, results of the most widely used behavioral assessment, water maze performance, are generally limited to 1-2 endpoints. Here, male APP/PS1 and noncarrier wildtypes (n=11/group) were assessed at 7-15 months of age for water maze,...

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Source

Identifiers

PMID: 23295401
DOI: 10.1016/j.bbr.2012.12.055

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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