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Article

Effect of Environmental Enrichment on the Immunoendocrine Aging of Male and Female Triple-Transgenic 3xTg-AD Mice for Alzheimer's Disease

5 Aug 2011

Abstract excerpt

We have previously shown that 3xTgAD mice (triple-transgenic mice for Alzheimer's disease, harboring PS1(M146V), AβPP(Swe), tau(P301L) transgenes) suffer detrimental changes in some key lymphocyte functions, described as health and longevity markers, with males being more affected than females and showing higher mortality rates. In the present work, 3xTgAD and wild type 129/C57BL6 male and female non- and...

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PMID: 21593564
DOI: 10.3233/jad-2011-110236

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