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Article

Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.

Journal of the neurological sciences - 15 Dec 2013

Lok Kenghoe, Zhao Hong, Zhang Can, He Na, Shen Hanlin, Wang Zejian, Zhao Wenjuan, Yin Ming

Abstract excerpt

Alzheimer's disease (AD) is characterized by a deficit in motor and spatial learning-memory and alteration of non-cognitive behavior. The generation of transgenic mice with presence of AD pathologies that cause learning and memory deficits has led to improved understanding of the behavioral and pathophysiological processes underlying AD. A novel APP/PS1 mouse model in the senescence accelerated mouse prone 8...

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Source

Identifiers

PMID: 24095271
DOI: 10.1016/j.jns.2013.09.018

Genes

APP
GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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