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Article

Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Mar 2007

Chen Guiquan, Chen Karen S, Kobayashi Dione, Barbour Robin, Motter Ruth, Games Dora, Martin Stephen J, Morris Richard G M

Abstract excerpt

The behavioral and biochemical impact of active immunization against human beta-amyloid (Abeta) was assessed using male transgenic (Tg) mice overexpressing a human mutant amyloid precursor protein (heterozygous PDAPP mice) and littermate controls. Administration of aggregated Abeta42 occurred at...

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Identifiers

PMID: 17344403
DOI: 10.1523/JNEUROSCI.3710-06.2007
PMCID: PMC6672499

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MPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17344403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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