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AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging

16 Aug 2016

Abstract excerpt

Cerebellar pathology has been related to presenilin 1 mutations in certain pedigrees of familial Alzheimer's disease. However, cerebellum tissue has not been intensively analyzed in transgenic models of mutant presenilins. Furthermore, the effect of the sex of the mice was not systematically analyzed, despite the fact that important gender differences in the evolution of the disease in the human population have...

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PMID: 27567877
DOI: 10.3233/jad-160572

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