Article

PET Imaging of the Serotonin 1A Receptor in Major Depressive Disorder: Hierarchical Multivariate Analysis of [ <sup>11</sup> C]WAY100635 Overcomes Outcome Measure Discrepancies

2024-03-12

Abstract excerpt

<h4>ABSTRACT</h4> The serotonin 1A receptor has been linked to both the pathophysiology of major depressive disorder (MDD) and the antidepressant action of serotonin reuptake inhibitors. Most PET studies of the serotonin 1A receptor in MDD used the receptor antagonist radioligand, [carbonyl- 11 C]WAY100635; however the interpretation of the combined results has been contentious owing to reports of higher or lowe...

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Literature Corpus work: dc297e6d-b9f5-5b3f-8578-a97d0050d742
DOI: 10.1101/2024.03.12.584569

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