Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain.

NeuroImage - 1 Jul 2014

Lan Martin J, Ogden R Todd, Huang Yung-Yu, Oquendo Maria A, Sullivan Gregory M, Miller Jeffrey, Milak Matthew, Mann J John, Parsey Ramin V

Abstract excerpt

Brain Derived Neurotrophic Factor (BDNF) regulates brain synaptic plasticity. BDNF affects serotonin signaling, increases serotonin levels in brain tissue and prevents degeneration of serotonin neurons. These effects have hardly been studied in human brain. We examined the relationship of the functional val66met polymorphism of the BDNF gene to serotonin 1A (5-HT(1A)) receptor binding in vivo. 50 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Piperazines

Share to Positron-Emission Tomography

Share to Pyridines

Share to Radiopharmaceuticals

Share to Receptor, Serotonin, 5-HT1A

Share to Statistics as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 24607934
DOI: 10.1016/j.neuroimage.2014.02.027
PMCID: PMC4033823

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain.PMID 24607934Read ↗

Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding.Semantic proximity Read ↗

BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels.Semantic proximity Read ↗

Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men.Semantic proximity Read ↗

BDNF val66met association with serotonin transporter binding in healthy humansSemantic proximity Read ↗

Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.Semantic proximity Read ↗

Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo.Semantic proximity Read ↗

Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning.Semantic proximity Read ↗

Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder.Semantic proximity Read ↗

BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.Semantic proximity Read ↗

The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.