Article
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study.
Translational psychiatry - 17 Apr 2012
Hammer C, Cichon S, Mühleisen T W, Haenisch B, Degenhardt F, Mattheisen M, Breuer R, Witt S H, Strohmaier J, Oruc L, Rivas F, Babadjanova G, Grigoroiu-Serbanescu M, Hauser J, Röth R, Rappold G, Rietschel M, Nöthen M M, Niesler B
Abstract excerpt
Serotonin type 3 receptors (5-HT(3)) are involved in learning, cognition and emotion, and have been implicated in various psychiatric phenotypes. However, their contribution to the pathomechanism of these disorders remains elusive. Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot...
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