Article
Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2015
Kaufman Joshua, Sullivan Gregory M, Yang Jie, Ogden R Todd, Miller Jeffrey M, Oquendo Maria A, Mann J John, Parsey Ramin V, DeLorenzo Christine
Abstract excerpt
Multiple lines of research have implicated the serotonin 1A (5-HT1A) receptor in major depressive disorder (MDD). Despite this, quantification of 5-HT1A is yet to yield a clinically relevant MDD biomarker. One reason may be that reported sex differences in the serotonergic system confound the comparison between diagnostic groups. Therefore, this study sought to determine whether differences in 5-HT1A binding...
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