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Article

Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?

Clinical chemistry and laboratory medicine - 1 Jan 2009

Petrásek Jan, Hubácek Jaroslav A, Stickel Felix, Sperl Jan, Berg Thomas, Ruf Esther, Wichmann H-Erich, Pfeufer Arne, Meitinger Thomas, Trunecka Pavel, Spicák Julius, Jirsa Milan

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA -238A, IL1B -31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-alpha and IL-1beta, respectively. Alleles CD14 -159T, TLR4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19278365
DOI: 10.1515/CCLM.2009.112

Genes

TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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