Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence.

Alcoholism, clinical and experimental research - 1 Nov 2009

Marcos Miguel, Pastor Isabel, González-Sarmiento Rogelio, Laso Francisco Javier

Abstract excerpt

BACKGROUND: The genetic basis for the predisposition to alcoholic liver cirrhosis (ALC) remains unknown. Increasing evidence supports a role for the nuclear factor (NF)-kappaB, the NF-kappaB inhibitor alpha (NFKBIA), and the peroxisome proliferator-activated receptor (PPAR)-gamma in the pathogenesis of alcoholic liver disease, raising the possibility that common polymorphisms in genes encoding these molecules may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis, Alcoholic

Share to Logistic Models

Share to NF-kappa B p50 Subunit

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 19673747
DOI: 10.1111/j.1530-0277.2009.01023.x

Genes

NFKB1
NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence.PMID 19673747Read ↗

Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol AbuseSemantic proximity Read ↗

Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China.Semantic proximity Read ↗

Common Polymorphisms in the NFKBIA Gene and Cancer Susceptibility: A Meta-Analysis.Semantic proximity Read ↗

Genetic Variation in NFKB1 Gene Influences Liver Enzyme Levels in Morbidly Obese Women.Semantic proximity Read ↗

Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.Semantic proximity Read ↗

The -94Ins/DelATTG polymorphism in NFκB1 promoter modulates chronic hepatitis C and liver disease progression.Semantic proximity Read ↗

Genetic variation on the NFKB1 genes associates with the outcomes of HCV infection among Chinese Han population.Semantic proximity Read ↗

Association of inflammation genes with alcohol dependence/abuse: a systematic review and a meta-analysis.Semantic proximity Read ↗

PNPLA3 rs738409 associates with alcoholic liver cirrhosis but not with serum levels of IL6, IL10, IL8 or CCL2 in the Russian population.Semantic proximity Read ↗

IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C.Semantic proximity Read ↗

Influence of polymorphisms in TNF-α and IL1β on susceptibility to alcohol induced liver diseases and therapeutic potential of miR-124-3p impeding TNF-α/IL1β mediated multi-cellular signaling in liver microenvironment.Semantic proximity Read ↗

Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.