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Article

Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease.

Scandinavian journal of gastroenterology - 1 Jan 2008

Von Hahn Thomas, Halangk Juliane, Witt Heiko, Neumann Konrad, Müller Tobias, Puhl Gero, Neuhaus Peter, Nickel Renate, Beuers Ulrich, Wiedenmann Bertram, Berg Thomas

Abstract excerpt

OBJECTIVE: The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex. This inflammatory pathway can be influenced by alterations in genes encoding for LPS receptor components. Thus, a -260 C>T transition in the CD14 promoter is thought to result in enhanced CD14 expression thereby increasing the LPS responsiveness in chronic liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18415752
DOI: 10.1080/00365520701806065

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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