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Article

Genetic variation in TNFA predicts protection from severe bacterial infections in patients with end-stage liver disease awaiting liver transplantation.

Journal of hepatology - 1 Apr 2014

Senkerikova Renata, de Mare-Bredemeijer Emmeloes, Frankova Sona, Roelen Dave, Visseren Thijmen, Trunecka Pavel, Spicak Julius, Metselaar Herold, Jirsa Milan, Kwekkeboom Jaap, Sperl Jan

Abstract excerpt

BACKGROUND & AIMS: Augmented susceptibility to infections increases mortality in patients with end-stage liver disease (ESLD). We sought to determine the contribution of selected genetic variants involved in inflammatory signalling downstream of the Toll-like receptor 4 (TLR4) to severe bacterial infections (SBIs) in patients with ESLD. METHODS: We retrospectively assessed incidence of SBIs in 336 adult ESLD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24361409
DOI: 10.1016/j.jhep.2013.12.011

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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