Article
Polymorphisms of the CD14 genes are associated with susceptibility to alcoholic liver disease in Greek patients.
Alcoholism, clinical and experimental research - 1 Feb 2013
Nezi Vasiliki, Deutsch Melanie, Gazouli Maria, Alexopoulou Alexandra, Paparrigopoulos Thomas, Liappas Ioannis A, Dourakis Spyros P
Abstract excerpt
BACKGROUND: The incidence and severity of alcoholic liver disease (ALD) in chronic drinkers has been found to correlate with some environmental factors and especially with the dose of alcohol consumption, but it is obvious that other parameters clearly contribute to individual alcohol susceptibility. Chronic ethanol exposure leads to continuous endotoxin-mediated Toll-like receptor-4 (TLR-4) and CD14 activation...
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