Article
Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease.
Hepatology (Baltimore, Md.) - 1 May 2001
Järveläinen H A, Orpana A, Perola M, Savolainen V T, Karhunen P J, Lindros K O
Abstract excerpt
Twin concordance studies indicate that genetic factors influence the individual susceptibility for alcoholic liver disease (ALD). Both clinical and experimental data suggest that Kupffer cell activation by gut-derived endotoxins and other bacterial products is an important pathogenic factor. Acti...
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