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Article

Does the simultaneous tumor necrosis factor receptor 2, tumor necrosis factor promoter gene polymorphism represent a higher risk for alcoholic liver disease?

European journal of gastroenterology & hepatology - 1 Feb 2009

Machado Mariana Verdelho, Martins Alexandra, Almeida Rosário, Marques-Vidal Pedro, Gonçalves Maria S, Camilo Maria E, Cortez-Pinto Helena

Abstract excerpt

BACKGROUND AND AIM: Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that seems to play a crucial role in the pathogenesis of alcoholic liver disease (ALD). TNF-alpha exerts its effects by binding to specific receptors (TNFR); the polymorphism of TNFRII T587G has been associated with increased TNF apoptotic response and its presence may increase the risk to develop liver disease. The aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Tumor Necrosis Factor, Type II

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Source

Identifiers

PMID: 19212208
DOI: 10.1097/MEG.0b013e32831016e0

Genes

TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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