Article
Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies.
Annals of hematology - 1 Jul 2010
Bacher Ulrike, Haferlach Claudia, Schnittger Susanne, Kohlmann Alexander, Kern Wolfgang, Haferlach Torsten
Abstract excerpt
Despite recent progress in molecular research in myeloid malignancies, in subsets of patients with myelodysplastic syndrome (MDS) so far no underlying mutation was identified. In the myeloproliferative neoplasms (MPNs), the JAK2V617F alone cannot explain the phenotypic heterogeneity. In acute myeloid leukemia (AML), clinical variability exists within distinct subgroups. Thus, the search for novel molecular...
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