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Article

Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.

The Journal of biological chemistry - 15 Oct 2010

Fernandes Margret S, Reddy Mamatha M, Croteau Nicole J, Walz Christoph, Weisbach Henry, Podar Klaus, Band Hamid, Carroll Martin, Reiter Andreas, Larson Richard A, Salgia Ravi, Griffin James D, Sattler Martin

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by multiple mutagenic events that affect proliferation, survival, as well as differentiation. Recently, gain-of-function mutations in the α helical structure within the linker sequence of the E3 ubiquitin ligase CBL have been associated with AML. We identified four novel CBL mutations, including a point mutation (Y371H) and a putative splice site mutation in AML...

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Source

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Identifiers

PMID: 20622007
DOI: 10.1074/jbc.M110.106161
PMCID: PMC2952262

Genes

CBL
FLT3
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.PMID 20622007Read ↗

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CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.Semantic proximity Read ↗

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.Semantic proximity Read ↗

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