Article
Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis.
Progress in neuro-psychopharmacology & biological psychiatry - 15 Jun 2009
Ujike Hiroshi, Katsu Takeshi, Okahisa Yuko, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Uchimura Naohisa, Yamada Mitsuhiko, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi
Abstract excerpt
D2-like receptors are key targets for methamphetamine in the CNS, and their activation is an initial and indispensable effect in the induction of dependence and psychosis. It is possible that genetic variants of D2-like receptors may affect individual susceptibility to methamphetamine dependence and psychosis. To test this hypothesis, 6 putatively functional polymorphisms of D2-like receptors, -141C Ins/Del,...
Topics
- Adult
- Case-Control Studies
- Central Nervous System Stimulants
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype