Article
Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients.
Psychopharmacology - 1 Feb 2012
Koning Jeroen P, Vehof Jelle, Burger Huibert, Wilffert Bob, Al Hadithy Asmar, Alizadeh Behrooz, van Harten Peter N, Snieder Harold
Abstract excerpt
RATIONALE: Pharmacogenetic studies on antipsychotic-induced movement disorders (MD) in schizophrenia so far have focused mainly on tardive dyskinesia. Only a few examined the more acute antipsychotic-induced MD such as parkinsonism and akathisia. Notably, all MD relate to deregulation of the dopamine system. OBJECTIVE: This study aimed to replicate previously reported associations in candidate genes for acute and...
Topics
- Acute Disease
- Adolescent
- Adult
- Antipsychotic Agents
- Dyskinesia, Drug-Induced
- Female
- Genetic Association Studies
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Movement Disorders
- Polymorphism, Single Nucleotide