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Article

Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2011

Chen Dingyan, Liu Fang, Shang Qinggang, Song Xiaoqin, Miao Xiaoping, Wang Zengzhen

Abstract excerpt

Several studies have assessed the association between genetic polymorphisms of DRD2 and DRD4 genes and opioid dependence risk, while the results were inconsistent. We performed a meta-analysis, including 6,846 opioid dependence cases and 4,187 controls from 22 individual studies, to evaluate the roles of four variants (DRD2 -141ins/delC, rs1799732; DRD2 311 Ser > Cys, rs1801028; DRD2-related TaqI A, rs1800497 and...

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Share to Alleles
Share to Analgesics, Opioid
Share to Gene Frequency
Share to Genetic Predisposition to Disease
Share to Opioid-Related Disorders
Share to Polymorphism, Single Nucleotide
Share to Receptors, Dopamine D2
Share to Receptors, Dopamine D4

Source

Identifiers

PMID: 21714067
DOI: 10.1002/ajmg.b.31208

Genes

DRD2
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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