Article
The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population.
Behavioral and brain functions : BBF - 30 Aug 2010
Kobayashi Hideaki, Ujike Hiroshi, Iwata Nakao, Inada Toshiya, Yamada Mitsuhiko, Sekine Yoshimoto, Uchimura Naohisa, Iyo Masaomi, Ozaki Norio, Itokawa Masanari, Sora Ichiro
Abstract excerpt
BACKGROUND: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis. METHODS: We first analyzed...
Topics
- Adult
- Alleles
- Amphetamine-Related Disorders
- Asian People
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Polymorphism, Single Nucleotide
- Psychoses, Substance-Induced