The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment.

doi:10.1016/j.psychres.2012.06.024

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Article

The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment.

Psychiatry research - 30 Dec 2012

Wang Yingcheng, Liu Xiang, Yu Yue, Han Yuanyuan, Wei Jinxue, Collier David, Li Tao, Ma Xiaohong

Abstract excerpt

The study analyzed the effect of dopamine 2 receptor gene (DRD2) polymorphism on the risk for major depressive disorder (MDD) and the response to selective serotonin reuptake inhibitors (SSRIs). The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response.

Topics

Adult
Antidepressive Agents
Depressive Disorder, Major
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Dopamine D2
Selective Serotonin Reuptake Inhibitors
Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 22796099
DOI: 10.1016/j.psychres.2012.06.024

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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