Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease.

Gut - 1 Aug 2009

Brand S

Abstract excerpt

Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory Th17 cells, a novel T cell population characterised by the master transcription factor RORgammat, the surface markers IL23R and CCR6, and by production of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crohn Disease
Share to Cytokines
Share to Interleukin-23

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukins

Share to Intestines

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Helper-Inducer

Share to Th1 Cells

Source

Identifiers

PMID: 19592695
DOI: 10.1136/gut.2008.163667

Genes

CCR6
CCL20
JAK2
STAT3
TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease.PMID 19592695Read ↗

The Th17 Cell Population and the Immune Homeostasis of the Gastrointestinal TractSemantic proximity Read ↗

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel diseaseSemantic proximity Read ↗

Th17 Cells as Potential Probiotic Therapeutic Targets in Inflammatory Bowel Diseases.Semantic proximity Read ↗

Th17 plasticity and its changes associated with inflammatory bowel disease.Semantic proximity Read ↗

Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.Semantic proximity Read ↗

The IL‐17 pathway as a major therapeutic target in autoimmune diseasesSemantic proximity Read ↗

Th17 cells in immunity and autoimmunity.Semantic proximity Read ↗

Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders.Semantic proximity Read ↗

Functional and phenotypic heterogeneity of Th17 cells in health and diseaseSemantic proximity Read ↗

Th17 plasticity and its relevance to inflammatory bowel diseaseSemantic proximity Read ↗

Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease.Semantic proximity Read ↗

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.