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Article

Main features of human T helper 17 cells.

Annals of the New York Academy of Sciences - 1 May 2013

Annunziato Francesco, Cosmi Lorenzo, Liotta Francesco, Maggi Enrico, Romagnani Sergio

Abstract excerpt

In addition to T helper type 1 (Th1) and Th2 cells, Th17 cells are a third arm of effector CD4(+) T cells. Human Th17 cells express RORC and CD161 and originate from RORC-expressing CD161(+) precursors, which migrate to lymphoid tissue and differentiate into mature Th17 cells in response to interleukin (IL)-1β and IL-23. Human Th17 cells are rare in inflammed tissues for two reasons: (1) Th17 cells do not produce...

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Identifiers

PMID: 23651196
DOI: 10.1111/nyas.12075

Genes

RORC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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