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Article

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

Nature genetics - 1 Feb 2007

Rahman Nazneen, Seal Sheila, Thompson Deborah, Kelly Patrick, Renwick Anthony, Elliott Anna, Reid Sarah, Spanova Katarina, Barfoot Rita, Chagtai Tasnim, Jayatilake Hiran, McGuffog Lesley, Hanks Sandra, Evans D Gareth, Eccles Diana, Easton Douglas F, Stratton Michael R

Abstract excerpt

PALB2 interacts with BRCA2, and biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause Fanconi anemia. We identified monoallelic truncating PALB2 mutations in 10/923 individuals with familial breast cancer compared with 0/1,084 controls (P = 0.0004) and show that such mutations confer a 2.3-fold higher risk of breast cancer (95% confidence interval (c.i.) = 1.4-3.9, P =...

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to Genetic Predisposition to Disease

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Source

Open in PubMed Open full text

Identifiers

PMID: 17200668
DOI: 10.1038/ng1959
PMCID: PMC2871593

Genes

PALB2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.PMID 17200668Read ↗

PALB2/FANCN: recombining cancer and Fanconi anemia.Semantic proximity Read ↗

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.Semantic proximity Read ↗

Integrated Bioinformatics Analysis of PALB2 Reveals Expression Patterns, Molecular Interactions, and Prognostic Significance in Breast CancerSemantic proximity Read ↗

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Molecular analysis of PALB2-associated breast cancers.Semantic proximity Read ↗

Novel germline PALB2 truncating mutations in African American breast cancer patients.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.Semantic proximity Read ↗

Analysis of PALB2/FANCN-associated breast cancer families.Semantic proximity Read ↗

Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.Semantic proximity Read ↗

Role of PALB2 Polymorphisms with Regard to Susceptibility to Female Breast Cancer Risk in the Chinese Population.Semantic proximity Read ↗

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