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Article

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

Free radical biology & medicine - 15 May 2009

Emerling Brooke M, Weinberg Frank, Snyder Colleen, Burgess Zach, Mutlu Gökhan M, Viollet Benoit, Budinger G R Scott, Chandel Navdeep S

Abstract excerpt

AMP-activated protein kinase (AMPK) is a sensor of cellular energy status found in metazoans that is known to be activated by stimuli that increase the cellular AMP/ATP ratio. Full activation of AMPK requires specific phosphorylation within the activation loop of the catalytic domain of the alpha-subunit by upstream kinases such as the serine/threonine protein kinase LKB1. Here we show that hypoxia activates AMPK...

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Identifiers

PMID: 19268526
DOI: 10.1016/j.freeradbiomed.2009.02.019
PMCID: PMC3326346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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