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Article

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Hwang Ara B, Ryu Eun-A, Artan Murat, Chang Hsin-Wen, Kabir Mohammad Humayun, Nam Hyun-Jun, Lee Dongyeop, Yang Jae-Seong, Kim Sanguk, Mair William B, Lee Cheolju, Lee Siu Sylvia, Lee Seung-Jae

Abstract excerpt

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and mech...

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Identifiers

PMID: 25288734
DOI: 10.1073/pnas.1411199111
PMCID: PMC4210294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25288734-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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